NFL Week 3 2022: Picks and predictions for every game

It’s already the final full week of the September slate for the 2022 NFL season, and we make our picks for who walks into October as winners.

As always, al lines are provided by our partners at WynnBet.

Matchup

Pittsburgh Steelers

1-1

Cleveland Browns

1-1

Thursday, Sept. 29

8:15 p.m. ET

AMAZON

CLE -4.5

Nothing says primetime football like Mitch Trubisky and Jacoby Brissett throwing for 5.5 yards per attempt in an all-you-can-eat check down fest.

Pick: Cleveland 17, Pittsburgh 14

Matchup

Houston Texans

0-1-1

Chicago Bears

1-1

Sunday, Oct. 2

1 p.m. ET

CBS

CHI -3

If you’re watching this game, or you even plan to watch this game, seek help. Love yourself more. Consider better alternatives like spending a year with your in-laws or raking someone else’s lawn.

Pick: Chicago 19, Houston 17

Matchup

Las Vegas Raiders

0-2

Tennessee Titans

0-2

Sunday, Oct. 2

1 p.m. ET

Whoever loses is done, right? Not really. The Titans play in a horrid division, so they’d have hope. The Raiders, however, would be toast. They aren’t rebounding from 0-3 in the AFC West.

Pick: Las Vegas 31, Tennessee 27

Matchup

Kansas City Chiefs

2-0

Indianapolis Colts

0-1-1

Sunday, Oct. 2

1 p.m. ET

CBS

KC -6.5

One would expect the Colts, in their home opener, to come out with everything they have. The problem is they now employ defensive coordinator Gus Bradley, who last year with Las Vegas, saw his defense allow 89 points and seven touchdown passes to Patrick Mahomes and the Chiefs.

Pick: Kansas City 30, Indianapolis 20

Matchup

Buffalo Bills

2-0

Miami Dolphins

2-0

Sunday, Oct. 2

1 p.m. ET

CBS

BUF -5.5

Best game of the week? Arguably. Two undefeated teams clash for the AFC East lead. Two questions face the Dolphins: can they block, and can they get a stop?

Pick: Buffalo 34, Miami 23

Matchup

Detroit Lions

1-1

Minnesota Vikings

1-1

Sunday, Oct. 2

1 p.m. ET

FOX

MIN -6

This could go either way. If the Lions can create a few turnovers, they have a shot. The problem for them? This game isn’t in primetime, which means Kirk Cousins is about to look like Joe Montana.

Pick: Minnesota 28, Detroit 24

Matchup

Baltimore Ravens

1-1

New England Patriots

1-1

Sunday, Oct. 2

1 p.m. ET

FOX

BAL -3

The Ravens have to rebound after that miserable disaster of a fourth quarter on Sunday, and they should, because they’re more talented than New England in all three phases.

Pick: Baltimore 24, New England 20

Matchup

Cincinnati Bengals

0-2

New York Jets

1-1

Sunday, Oct. 2

1 p.m. ET

CBS

CIN -5

If the Bengals lose to the Jets, it’s over. Joe Burrow has been sacked 13 times in two games. Can New York get enough pressure to turn the tide in its favor?

Pick: Cincinnati 27, New York 17

Matchup

Philadelphia Eagles

2-0

Washington Commanders

1-1

Sunday, Oct. 2

1 p.m. ET

FOX

PHI -6.5

Philadelphia has a chance to run its record to 3-0, but needs to win on the road against an old friend and a divisional foe. This won’t be easy, but the Eagles are the better team with a much better defense.

Pick: Philadelphia 31, Washington 26

Matchup

New Orleans Saints

1-1

Carolina Panthers

0-2

Sunday, Oct. 2

1 p.m. ET

After watching Jameis Winston throw three interceptions amidst five New Orleans turnovers last week, Saints fans have to be hoping for a bounce-back showing. They should get one against Baker Mayfield and the Panthers, who haven’t shown much early.

Pick: New Orleans 24, Carolina 22

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