The 2022 NFL regular season is here, and we’re rolling through our Week 1 picks, starting with the defending champs and the Super Bowl favorites.
As always, all odds are courtesy of WynnBet.
Matchup
Buffalo Bills
0-0
Los Angeles Rams
0-0
Thursday, Sept. 8
8:20 p.m. ET
NBC
BUF -2.5
Emotional night in Los Angeles. Super Bowl banner, homecoming for heroes. Is it enough to get past the Bills, who might have the best roster in football? Perhaps not.
Pick: Buffalo 31, Los Angeles 26
Matchup
New Orleans Saints
0-0
Atlanta Falcons
0-0
Sunday, Sept. 11
1 p.m. ET
FOX
NO -5.5
This is an underrated rivalry, and one the Saints will enjoy this season. New Orleans is quite underrated, and the Falcons might have the worst roster in the league. How many players can you name on Atlanta? No way it’s more than 10.
Pick: New Orleans 24, Atlanta 15
Matchup
San Francisco 49ers
0-0
Chicago Bears
0-0
Sunday, Sept. 11
1 p.m. ET
We finally get the Trey Lance era in San Francisco, and it begins against his classmate in Bears quarterback Justin Fields. The Niners are a Super Bowl contender if Lance plays well, while Chicago is trying to begin a rebuild.
Pick: San Francisco 27, Chicago 14
Matchup
Pittsburgh Steelers
0-0
Cincinnati Bengals
0-0
Sunday, Sept. 11
1 p.m. ET
CBS
CIN -6.5
The Bengals have been talked about as a popular regression candidate. You won’t hear that in this space. Cincinnati is loaded and while Pittsburgh’s defense is a real test, its offense remains a questionable outfit.
Pick: Cincinnati 23, Pittsburgh 19
Matchup
Philadelphia Eagles
0-0
Detroit Lions
0-0
Sunday, Sept. 11
1 p.m. ET
FOX
PHI -4
We go with the upset here. The Lions aren’t as good as Philadelphia, but Detroit has real talent for the first time in years, while the Eagles are on the road and still hoping to see Jalen Hurts take the step from good to star. He might, but this is only Week 1.
Pick: Detroit 20, Philadelphia 19
Matchup
New England Patriots
0-0
Miami Dolphins
0-0
Sunday, Sept. 11
1 p.m. ET
CBS
MIA -2.5
The Dolphins have always given the Patriots a tough time, and swept them last year. Now, it feels like Miami is ascending while New England is sinking. The Dolphins have plenty to prove, but they should get off to a good start.
Pick: Miami 24, New England 20
Matchup
Baltimore Ravens
0-0
New York Jets
0-0
Sunday, Sept. 11
1 p.m. ET
CBS
BAL -7
Lock of the week. The Ravens are an excellent team that was besieged by injuries in 2021. Healthy once again, they take on a Jets squad which has a backup quarterback, a shaky defense and an offense waiting for Zach Wilson to return.
Pick: Baltimore 34, New York 14
Matchup
Jacksonville Jaguars
0-0
Washington Commanders
0-0
Sunday, Sept. 11
1 p.m. ET
FOX
WSH -3
Quietly, a fascinating game. Jacksonville now has a real coach, and Washington is hoping Carson Wentz proves an upgrade. Both teams could be sneaky playoff contenders, and both could finish 6-11.
Pick: Washington 24, Jacksonville 22
Matchup
Cleveland Browns
0-0
Carolina Panthers
0-0
Sunday, Sept. 11
1 p.m. ET
CBS
CAR -1.5
The Baker Mayfield Revenge Game. This might not be a great Carolina team, but this is the ultimate bad spot for Cleveland. Mayfield is furious, the Browns are starting Jacoby Brissett, it’s a road game and the Panthers are finally healthy for once.
Pick: Carolina 28, Cleveland 21
Matchup
Indianapolis Colts
0-0
Houston Texans
0-0
Sunday, Sept. 11
1 p.m. ET
CBS
IND -5
The Texans are essentially waiting for next year, while the Colts are rebooting with Matt Ryan under center. Indianapolis isn’t a high-flying team, but it should score plenty against what appears to be a poor Houston defense.
Pick: Indianapolis 30, Houston 17