NFL Week 6 2022: Picks and predictions for every game

It’s time to make our NFL Week 6 picks, and there are some of the year’s best games on the slate for Sunday afternoon and evening.

As always, all odds are provided by our partners at WynnBet

Matchup

Washington Commanders

1-4

Chicago Bears

2-3

Thursday, Oct. 13

8:20 p.m. ET

AMAZON

CHI -1

Go see a movie. Grab dinner with a friend in a restaurant without televisions. Mow the lawn by moonlight. Anything.

Pick: Washington 20, Chicago 17

Matchup

Baltimore Ravens

3-2

New York Giants

4-1

Sunday, Oct. 16

1 p.m. ET

CBS

BAL -5

Wink Martindale against Lamar Jackson. This is going to be fascinating stuff. Baltimore better be ready for every blitz imaginable.

Pick: Baltimore 23, New York 21

Matchup

Cincinnati Bengals

2-3

New Orleans Saints

2-3

Sunday, Oct. 16

1 p.m. ET

CBS

CIN -2

The Bengals are the better team, but it’s never easy playing in the Superdome. Of course, for Joe Burrow, the building has fond memories from his LSU days.

Pick: Cincinnati 30, New Orleans 22

Matchup

Jacksonville Jaguars

2-3

Indianapolis Colts

2-2-1

Sunday, Oct. 16

1 p.m. ET

CBS

IND -2.5

This division should be put out to pasture. Just brutal football all the way around. That said, somehow, the Colts might eclipse .500.

Pick: Indianapolis 18, Jacksonville 16

Matchup

Minnesota Vikings

4-1

Miami Dolphins

3-2

Sunday, Oct. 16

1 p.m. ET

FOX

MIN -3

The Vikings are playing (pretty) good football, while the Dolphins are really beat up. Feels like a third straight loss for the Fins.

Pick: Minnesota 31, Miami 20

Matchup

New York Jets

3-2

Green Bay Packers

3-2

Sunday, Oct. 16

1 p.m. ET

The Jets can absolutely win this game, largely because the Packers can absolutely find a way to lose this game. Still, it’s at Lambeau, and the Packers need it.

Pick: Green Bay 24, New York 20

Matchup

New England Patriots

2-3

Cleveland Browns

2-3

Sunday, Oct. 16

1 p.m. ET

CBS

CLE -3

This is all about whether you believe Bill Belichick does enough to stymie Jacoby Brissett. I’m riding with Belichick here.

Pick: New England 21, Cleveland 19

Matchup

San Francisco 49ers

3-2

Atlanta Falcons

2-3

Sunday, Oct. 16

1 p.m. ET

FOX

SF -5.5

Atlanta could be catching the Niners on a good week. San Francisco has to fly cross-country, with a beat-up defense, with the Chiefs on deck. Look for the 49ers to win late.

Pick: San Francisco 27, Atlanta 20

Matchup